Weeber, M.; Klein, H.; Jong-van den Berg, L.T.W. de; Vos, R.: Using concepts in literature-based discovery : simulating Swanson's Raynaud-Fish Oil and Migraine-Manesium discoveries (2001)
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- Abstract
- Literature-based discovery has resulted in new knowledge. In the biomedical context, Don R. Swanson has generated several literature-based hypotheses that have been corroborated experimentally and clinically. In this paper, we propose a two-step model of the discovery process in which hypotheses are generated and subsequently tested. We have implemented this model in a Natural Language Processing system that uses biomedical Unified Medical Language System (UMLS) concepts as its unit of analysis. We use the semantic information that is provided with these concepts as a powerful filter to successfully simulate Swanson's discoveries of connecting Raynaud's disease with fish oil and migraine with a magnesium deficiency
